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CNPY2 is a key initiator of the PERK–CHOP pathway of the unfolded protein response

11:13 EDT 6 Sep 2017 | Nature Publishing

In vitro and in vivo data show that ER protein CNPY2 initiates the PERK–CHOP signaling pathway to trigger the unfolded protein response (UPR) and contributes to hepatic steatosis.

Original Article: CNPY2 is a key initiator of the PERK–CHOP pathway of the unfolded protein response

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