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Frontier Pharma: Cardiovascular Disease Diverse FirstinClass Molecular Targets to Bridge Unmet Needs in Pulmonary Hypertension, Heart Failure and Atherosclerosis
The cardiovascular disease CVD therapy area encompasses a range of different diseases and conditions affecting the heart and/or blood vessels. The most crucial risk factors for CVD are hypertension and dyslipidemia, which accelerate the development of atherosclerotic plaque building up within blood vessels. As atheroma develops it causes the affected blood vessels to narrow, restricting blood flow to the body, brain or heart, depending on its location. It is also possible for the fibrous cap of this plaque to break off, triggering the coagulation cascade and causing a thrombus to form locally, which can completely occlude blood flow.
The treatments of CVD typically focus on prevention by controlling the risk factors of CVD. As such, the treatments usually fall within three categories: antihypertensives, which aim to alterblood pressure to within a normal range; antidyslipidemic drugs, which aim to modify lipid levels to a normal range; and antithrombotic drugs, which aim to either prevent a thrombus from formingby inhibiting the coagulation cascade or platelet aggregation.
There has been vast scientific innovation within the CVD therapeutics market over recent decades, particularly within the antidyslipidemia market, first with the introduction of statins such as Lipitor atorvastatin, and more recently with the introduction of PCSK9 inhibitors. Innovation continues within the dyslipidemia pipeline, with a range of firstinclass molecular targets in the pipeline, including those that offer the promise of revolutionizing treatment by reversing the process of atherosclerosis.
Heart failure and pulmonary hypertension remain poorly treated, and are associated with poor prognosis. Heart failure in particular is associated with a fiveyear mortality rate of 50%. The large pipeline for heart failure includes a high proportion of firstinclass products relative to other CVD indications, and possesses the potential for breakthroughs in the treatment of this condition.
With over 1,400 products in active development, the pipeline for CVD is extensive. Does current pipeline innovation hold the potential to change the CVD market in the near future?
There are 320 firstinclass products in the CVD market that act on a novel molecular target thatis not present in an approved product across any indication in the pharmaceutical industry. Which of these hold the greatest potential to improve future disease treatment with regard to their molecular target?
Analysis of the history of strategic consolidations revealed a modest level of deal activity in recent years, and a large number of firstinclass products not yet involved in any deals. How do deal frequency and value compare between target families and molecule types, and which firstinclass programs that have not yet been involved in a licensing or codevelopment deal appear to be particularly promising?
Reasons to buy
Understand the current clinical and commercial landscape. This includes a comprehensive study of disease pathogenesis, diagnosis and prognosis, and the treatment options available.
Visualize the composition of the CVD market in terms of dominant molecule types and targets, highlighting what the current unmet needs are and how they can be addressed. This knowledge allows a competitive understanding of gaps in the current market.
Analyze the CVD pipeline and stratify by stage of development, molecule type and molecular target. There are strong signs in the pipeline that the industry is seeking novel approaches to treating CVD to overcome the unmet need in the market.
Assess the therapeutic potential of firstinclass targets. Using a proprietary matrix, firstinclass products have been assessed and ranked according to clinical potential. Promising earlystage targets have been reviewed in greater detail.
Identify commercial opportunities in the CVD deals landscape by analyzing trends in licensing and codevelopment deals, and analyzing a curated list of CVD therapies that have not yet been involved in deals, and may offer potential investment opportunities.
Original Article: Frontier Pharma: Cardiovascular Disease Diverse FirstinClass Molecular Targets to Bridge Unmet Needs in Pulmonary Hypertension, Heart Failure and Atherosclerosis [Report Updated: 01082017] Prices from USD $6995NEXT ARTICLE
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