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Stem Cell Factor-responsive FcepsilonRI Bearing Human Mast Cell Line LAD2

19:00 EST 31 Oct 2002 | NIH

A human mast cell line LAD2 that more closely resembles normal in vivo and in vitro human mast cells by expressing functional FcepsilonRI receptors and responding to stem cell factor (SCF) with proliferation, as described in Leuk Res. 2003 Aug;27(8):677-82 and developed by the laboratory of Dr. Dean Metcalfe at the National Institute of Allergy and Infectious Diseases.  This cell line also releases mediators by cross-linking FcgammaRI (CD64) receptors and express FcgammaRII (CD32).

IC: 
NIAID
NIH Ref. No.: 
E-279-2001/0
TAB No: 
TAB-641
Provider Technology ID: 
641
Updated On: 
Sep 19, 2017
Date Published: 
Friday, November 1, 2002
Provider Classifications: 
Patent Application: 
60/354,440
PCT/US03/02790
Publications: 
Patent Authority: 
EIR
US
PCT
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NIAID
NIAID
NIAID
Inventor Lab URL: 
https://irp.nih.gov/pi/dean-metcalfe
LPM FIrst Name: 
Dianca
LPM Last Name: 
Finch
LPM Address: 
BG 5601FL RM 2G58 MSC 9804 5601 FISHERS LN
LPM City: 
Bethesda
Inv Is lead: 
LPM Zip: 
20892
LPM State: 
MD
LPM Phone: 
240-669-5503
LPM Suffix: 
Ph.D.
LPM Organization: 
NIH Office of Technology Transfer
DTDT Classification: 
Internal Medicine
Diagnostics
Anti-Inflammatory (including Autoimmune)
Research Materials
Research Tool
DTDT Description: 
Internal Medicine
Internal Medicine - Diagnostics
Internal Medicine - Diagnostics: Anti-Inflammatory
Internal Medicine - Research Materials
Research Tool
Pat Filing Date: 
2002-02-04
2003-01-29
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/12801524
Publication Caption: 
PMID 12801524
Publication Title: 

Kirshenbaum AS, et al.

Additional Patents: 
Research Material - Patent protection is no longer being pursued for this technology. (IC Reference No. 2001-022)
Application Term: 
Collaboration Sought: 
Yes
Institute or Center: 
E Number Only: 
E-279-2001
Inventor First Name: 
Arnold
Cem
Dean
Inventor Last Name: 
Kirshenbaum
Akin
Metcalfe

Original Article: Stem Cell Factor-responsive FcepsilonRI Bearing Human Mast Cell Line LAD2

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