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"We can help predict response to immunotherapy by measuring the number of mutations in circulating tumor DNA [ctDNA] using a simple blood test," said Yulian Khagi, MD, UC San Diego Moores Cancer Center fellow and first author. "Immunotherapy can result in serious side effects, and therefore being able to predict who will respond is important to mitigating potential risk to each patient." The team's study ("Hypermutated Circulating Tumor DNA: Correlation with Response to Checkpoint Inhibitor–Based Immunotherapy"), published in Clinical Cancer Research, demonstrates that 45 percent of patients with more than three genomic alterations detected in ctDNA responded to checkpoint inhibitor-based immunotherapy. Patients with fewer alterations had a 15 percent response. "We assessed 69 patients with diverse malignancies who received checkpoint inhibitor–based immunotherapy and blood-derived ctDNA NGS testing (54–70 genes). Rates of stable disease (SD) ≥6 months, partial and complete response (PR, CR), progression-free survival (PFS), and overall survival (OS) were ...NEXT ARTICLE
Allergies Automimmune Disease Human Papillomavirus (HPV) Immunology Vaccine Immunology is the study of immunity and the defence mechanisms of the body. A greater understanding of immunology is needed to develop vaccines, understand ...
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...
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