Advertisement

Topics

sFRP and Peptide Motifs That Interact with sFRP and Methods of Their Use

19:00 EST 31 Mar 2003 | NIH

These patent applications describe and claim inventions related to the protein sFRP-1 and methods of regulating signal transduction pathways using sFRP-1. sFRP-1 is a member of a family of secreted proteins (secreted Frizzled Related Proteins) that were originally identified as being able to bind to Wnt proteins. When bound to Wnts, sFRP-1 alters the ability of Wnt protein to bind its receptor (Frizzled), typically acting as an antagonist of Wnt signaling.

More particularly, the patent applications and inventions claimed therein relate to methods for influencing bone remodeling using sFRP-1. In particular, the patent application and claimed inventions relate to methods of inhibiting osteoclastogenesis with the sFRP-1 protein. The ability to inhibit osteoclast formation may be of value in developing treatments for diseases such as post-menopausal osteoporosis, Paget's disease, lytic bone metastases, multiple myeloma, hyperparathyroidism, rheumatoid arthritis, periodontitis and hypercalcemia of malignancy.

In addition to describing the method of inhibiting osteoclast formation, the patent applications disclose various peptides containing a conserved motif that allows the peptide containing the motif to bind to sFRP-1.

IC: 
NCI
NIH Ref. No.: 
E-060-2000/0
TAB No: 
TAB-722
Advantages: 
  • Widely applicable to many diseases
  • Multiple peptides capable of binding sFRP-1
Applications: 
  • Peptide therapy for patients with various bone remolding diseases such as post-menopausal osteoporosis, Paget’s disease, rheumatoid arthritis, periodontitis and hypercalcemia
  • Applicable for the inhibition of osteoclast formation in patients
Provider Technology ID: 
722
Updated On: 
Oct 23, 2017
Provider Classifications: 
Date Published: 
Tuesday, April 1, 2003
Patent Application: 
60/260,908
PCT/US02/00869
10/466,136
12/019,567
Publications: 
Patent Authority: 
US
PCT
US
US
Patent Number: 
7,488,710
8,334,260
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NCI
EM
EM
NCI
EM
EM
Inventor Lab URL: 
http://irp.nih.gov/pi/jeffrey-rubin
LPM FIrst Name: 
Susan
LPM Last Name: 
Rucker
LPM Address: 
9609 Medical Center Drive, Room 1E-530 (MSC 9702)
LPM City: 
Rockville
Inv Is lead: 
LPM Zip: 
20850-9702
LPM State: 
MD
LPM Phone: 
240-276-6727
LPM Suffix: 
J.D.
LPM Organization: 
NIH Office of Technology Transfer
LPM Fax: 
240-276-5504
DTDT Classification: 
Cancer
Therapeutics
Biological Response Modifiers
Other
Other
Internal Medicine
Therapeutics
Anti-Inflammatory (including Autoimmune)
Other
Disease Initiatives, Rare Disease
DTDT Description: 
Cancer
Cancer - Therapeutics
Cancer - Therapeutics - Biological Response Modifiers
Cancer - Therapeutics - Biological Response Modifiers: Other
Cancer - Therapeutics: Other
Internal Medicine
Internal Medicine - Therapeutics
Internal Medicine - Therapeutics: Anti-Inflammatory
Internal Medicine - Therapeutics: Other
Disease Initiatives, Rare Disease
Pat Filing Date: 
2001-01-10
2002-01-10
2003-07-10
2008-01-24
Patent Issue Date: 
2009-02-10
2012-12-18
Additional Patents: 
International Patents issued in Australia, Canada, Japan, Austria, Belgium, Switzerland, Cyprus, Germany, Denmark, Spain, Finland, France, United Kingdom, Greece, Ireland, Italy, Liechtenstein, Luxembourg, Monaco, Netherlands, Portugal, Sweden, Turkey
Application Term: 
Disease Area Term: 
Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

Researchers at the NCI seek licensing and/or co-development research collaborations for the inhibition of osteoclast formation using peptides capable of binding sFRP-1.

E Number Only: 
E-060-2000
Inventor First Name: 
Jeffrey
Nicole
Brian
Aykut
Bernard
Matthew
Inventor Last Name: 
Rubin
Horwood
Kay
Uren
Weisblum
Gillespie

Original Article: sFRP and Peptide Motifs That Interact with sFRP and Methods of Their Use

NEXT ARTICLE

More From BioPortfolio on "sFRP and Peptide Motifs That Interact with sFRP and Methods of Their Use"

Quick Search
Advertisement
 

Relevant Topic

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...