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Secreted Frizzled Related Protein, sFRP, Fragments and Methods of Use Thereof

19:00 EST 30 Nov 2000 | NIH

This technology relates to signal transduction pathways and mechanisms. More particularly, the application describes various active fragments of the secreted Wnt binding protein sFRP-1 (secreted Frizzled Related Protein-1). The sFRP-1 fragments described are capable of binding to Wnt and therefore are able to modulate Wnt activity. The fragments may or may not contain the cysteine rich domain (CRD) of sFRP-1 suggesting that the CRD is not essential for Wnt binding. In addition, in contrast to earlier findings employing higher levels of sFRP-1, the ability of sFRP-1 to enhance Wnt signaling at low levels is also described suggesting biphasic regulation of Wnt signaling by sFRP-1. The sFRP-1 fragments described herein may be useful in the further study of Wnt signaling as well as targets for the development of small molecules which can modulate Wnt signaling.

IC: 
NCI
NIH Ref. No.: 
E-014-2000/0
TAB No: 
TAB-172
Advantages: 
  • sFRP-1 fragments directing bind Wnt o modulate Wnt activity
  • Capable of biphasic regulation of Wnt signaling
Applications: 
  • Treatment of patients with neoplasia using active fragments of sFRP
  • Further studying and understanding Wnt signaling
Provider Technology ID: 
172
Updated On: 
Oct 23, 2017
Date Published: 
Friday, December 1, 2000
Provider Classifications: 
Patent Application: 
09/546,043
10/425,586
11/748,872
13/031,060
13/426,520
Publications: 
Patent Authority: 
US
EIR
US
US
US
US
Patent Number: 
6,600,018
7,223,853
7,947,651
8,158,603
8,735,355
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NCI
NCI
Inventor Lab URL: 
http://irp.nih.gov/pi/jeffrey-rubin
LPM FIrst Name: 
Susan
LPM Last Name: 
Rucker
LPM Address: 
9609 Medical Center Drive, Room 1E-530 (MSC 9702)
LPM City: 
Rockville
LPM Zip: 
20850-9702
Inv Is lead: 
LPM State: 
MD
LPM Phone: 
240-276-6727
LPM Suffix: 
J.D.
LPM Organization: 
NIH Office of Technology Transfer
LPM Fax: 
240-276-5504
DTDT Classification: 
Cancer
Diagnostics
DNA Based
Therapeutics
Other
Research Materials
DTDT Description: 
Cancer
Cancer - Diagnostics
Cancer - Diagnostics - In Vitro: DNA Based
Cancer - Therapeutics
Cancer - Therapeutics - Biological Response Modifiers: Other
Cancer - Research Materials
Pat Filing Date: 
2000-04-10
2003-04-28
2007-05-15
2011-02-18
2012-03-21
Patent Issue Date: 
2003-07-29
2007-05-29
2011-05-24
2012-04-17
2014-05-27
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/10660608
Publication Caption: 
PMID 10660608
Publication Title: 

Uren A, et al.

Application Term: 
Disease Area Term: 
Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

Researchers at the NCI seek licensing and/or co-development research collaborations for active fragments of sFRP-1 capable of modulating Wnt activity.

Related Patents: 
7,488,710
8,334,260
Related Patent Publish Date: 
1010642400
1057813200
1201154400
Related Patent Application: 

PCT/US02/00869

10/466,136

12/019,567

Related Patent Authority: 
PCT
US
US
Related Invention: 
E-060-2000/1
E Number Only: 
E-014-2000
Inventor First Name: 
Jeffrey
Aykut
Inventor Last Name: 
Rubin
Uren

Original Article: Secreted Frizzled Related Protein, sFRP, Fragments and Methods of Use Thereof

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