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Collectively, cancer is the second leading cause of death in the United States. Current treatments of cancer often involve non-specific strategies (such as chemotherapy) which attack healthy cells as well as diseased cells, leading to harmful side-effects. As a result, the development of more targeted means of treating cancer are highly sought after. One option for a targeted treatment is the creation of a vaccine that induces an immune response only against cancer cells. In this sense, vaccination involves the introduction of a peptide into a patient that causes the formation of T cells that recognize the peptide. If the recognized peptide found is found selectively on cancer cells, T cells can trigger the death of those cancer cells without harming non-cancer cells. This can result in fewer side effects for the patient.
TARP (T cell receptor gamma alternate reading frame protein) is a protein that is selectively expressed on the cells of certain types of prostate and breast cancer. This invention concerns the identification of two synthetic 9-mer TARP peptides, and their use to create an anti-cancer immune response in patients. By introducing these peptides as a vaccine into a patient, an immune response against these cancer cells can be initiated by the peptides, resulting in treatment of the cancer.
Note: This invention is a component of the multi-epitope TARP vaccine (E-047-2014) that is now in Clinical Phase II. The Phase I study was completed and published.
Wood LV, et al.
Epel M, et al.
Oh S, et al.
Researchers at the NCI seek licensing and/or co-development research collaborations for a prostate cancer vaccine targeting the TARP antigen that has completed phase I clinical trials. For collaboration opportunities, please contact John Hewes, Ph.D. at email@example.com.
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...
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