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Researchers have discovered how an enzyme produced by immune system cells carries out a deadly, multipronged attack on invading bacteria. The enzyme, granzyme B, is released by cytotoxic T cells as part of the body’s natural fight against intracellular microbes. Collaborators at the University of Michigan and at Harvard University have now found that, unlike antibiotics, which disrupt a single bacterial process, granzyme B impacts on multiple bacterial processes all at the same time. The findings could potentially help scientists develop new antibiotics that are effective against existing multidrug-resistant pathogens and that prevent bacteria from developing resistance. Understanding how the enzyme exerts its multifaceted attack could also suggest how combinations of existing drugs might be repurposed to fight infection. “We have a huge crisis of antibiotic resistance right now in that most drugs that treat diseases like tuberculosis or listeria, or pathogens like E. coli , are not ...
Original Article: T-Cell Enzyme uses Deadly Multipronged Attack on BacteriaNEXT ARTICLE
Enzymes are proteins that catalyze (i.e., increase the rates of) chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical re...
Antiretroviral Therapy Clostridium Difficile Ebola HIV & AIDS Infectious Diseases Influenza Malaria Measles Sepsis Swine Flu Tropical Medicine Tuberculosis Infectious diseases are caused by pathogenic...
MRSA (methicillin-resistant Staphylococcus aureus)
MRSA (methicillin-resistant Staphylococcus aureus) is a family of bacteria with resistance to one or more major antibiotics. There are currently 17 different strains of MRSA. Two particular strains, EMRSA15 and EMRSA16 account for 96% of MRSA blood...