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Stem Cell Subset Source of All Blood Cells, Basis of Bone Marrow Transplant Success

06:50 EDT 2 Nov 2017 | Genetic Engineering News

A new blood system isn’t created from scratch—just something close to it. A single type of stem cell, a new study demonstrates, can fully repopulate the bone marrow and give rise to all the cell lineages that constitute a complete blood system. This blood-forming stem cell is distinguished by three surface markers—or rather the presence of two markers and the absence of a third. By heeding these markers, scientists may improve transplantation procedures, as well develop better gene therapy and gene editing approaches. The discovery was described November 1 in the journal Science Translational Medicine, in an article entitled, “A distinct hematopoietic stem cell population for rapid multilineage engraftment in nonhuman primates.” According to this article, CD34-positive hematopoietic stem cells (HSCs), long considered the gold standard for stem cell therapy and transplantation of stem cell–enriched grafts, do not all contribute to multilineage engraftment. In fact, few of ...

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