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Fat Cells Inactivate Cancer Chemotherapy

04:52 EST 8 Nov 2017 | Genetic Engineering News

Obesity is linked with poorer outcomes for patients with a range of cancers, including breast, colon, ovarian, and prostate. The results from new studies now indicate that fat cells in a tumor microenvironment (TME) can directly take up and metabolize at least one type of chemotherapy and so prevent the active drug  from reaching and killing the cancer cells. "The finding that human fat cells can metabolize and inactivate a chemotherapy is novel and surprising," says the study’s lead scientist Steven Mittelman, M.D., Ph.D., associate professor of pediatrics and the division chief of pediatric endocrinology at UCLA Mattel Children’s Hospital in Los Angeles. "This is important for leukemia and a lot of other cancers that grow in the bone marrow or around fat cells, since that means that fat cells might remove chemotherapy from the environment and allow the cancer cells to survive." Research has suggested that ...

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