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Could a Little Stress Be Healthy for Cells? New Study Says Yes!

05:57 EST 8 Nov 2017 | Genetic Engineering News

“A little dab’ll do ya!” That was the Brylcreem slogan for their hair product some 60 years ago. Now, it seems, that researchers at Northwestern University are applying the same motto to mitochondrial stress and cellular health. In a genetic study of the roundworm Caenorhabditis elegans , the investigators found that signals from mildly stressed mitochondria prevent the failure of protein-folding quality-control (proteostasis) machinery in the cytoplasm that comes with age. Findings from the new study—published recently in Cell Reports , in an article entitled “ Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging ”—could help researchers better understand the molecular mechanisms that drive aging and risk for age-associated degenerative diseases. Additionally, the research team noted that the stabilized proteostasis mechanisms from moderately stressed mitochondria suppressed the accumulation of damaged proteins that can occur in degenerative diseases, such as Alzheimer’s, Huntington’s, and Parkinson’s ...

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