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Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

21:41 EST 8 Nov 2017 | Nature Publishing

IgA+ B cells expressing programmed death ligand 1 (PD-L1) and interleukin 10 accumulate in the inflamed livers of humans and mice with non-alcoholic fatty liver disease where they promote the progression to hepatocellular carcinoma by limiting the local activation of PD-1-expressing CD8+ T cells.

Original Article: Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity

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