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In the era of platinum-based chemotherapy, attempts to improve the quality of life (QOL) of patients with advanced non-small-cell lung cancer (NSCLC) using a less toxic treatment than the existing standard therapy were often disappointing. In a randomised trial1 comparing cisplatin-based treatment to a so-called platinum-free combination chemotherapy, the goal of improving QOL was not met. The lesson learned was that in patients with a disease often associated with serious symptoms, reduction of treatment-related toxicity is not enough to improve global QOL, and more effective control of disease is needed to achieve a positive QOL balance.
Original Article: [Comment] Quality of life: an important element of treatment valueNEXT ARTICLE
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GILOTRIF (afatinib) is a kinase inhibitor indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L8...