Dogma Surrounding Brain Drainage System Overturned

05:33 EST 10 Nov 2017 | Genetic Engineering News

Researchers in Switzerland suggest that helping the brain to flush out toxic proteins could represent a new approach to preventing or treating age-related neurological disorders such as Alzheimer’s disease. Studies in mice by the team based at ETH Zurich and the University of Zurich have shown for the first time that the lymphatic system plays a key role in draining the cerebrospinal fluid (CSF) that bathes the brain, but that this function slows with age. “Our findings implicate that the lymphatic system has a greater than previously acknowledged role in many neurological conditions,” the researchers write in their published paper in Nature Communications (“ Outflow of Cerebrospinal Fluid Is Predominantly through Lymphatic Vessels and Is Reduced in Aged Mice ”). “If so, the lymphatic system may represent a possible new therapeutic target with the aim to enhance the clearance of toxic proteins from the CSF and the brain.” ...

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