Anxiety and Depression Target Identified for Treatment-Resistant Patients

04:49 EST 13 Nov 2017 | Genetic Engineering News

Studies by researchers in the U.S. suggest that a metabolite of progesterone may represent a new therapeutic target for depression and anxiety in otherwise treatment-resistant groups of patients, including those with anorexia nervosa. Collaborating scientists at Massachusetts General Hospital, the University of Illinois at Chicago, and Boston University School of Medicine, found low levels of the neuroactive steroid allopregnanolone (3α-5α-tetrahydroprogesterone, or ‘allo’) in both obese women and those with anorexia nervosa, and showed that levels of allo correlated with the severity of depression and anxiety symptoms. “We are beginning to see more and more evidence that low allo levels are tightly linked to depression, anxiety, post-traumatic stress disorder (PTSD) and other mood disorders,” comments co-researcher Graziano Pinna, associate professor of psychiatry at the University of Illionois at Chicago College of Medicine. “To see women with anorexia nervosa and obesity have low levels adds to the picture that the ...

Original Article: Anxiety and Depression Target Identified for Treatment-Resistant Patients


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Depression is a serious mental health condition, where sad feelings carry on for weeks or months and interfere with your life. The symptoms include feeling unhappy most of the time (but may feel a little better in the evenings), loosing interest in lif...

Anxiety Disorders
Anxiety is caused by stress. It is a natural reaction, and is beneficial in helping us deal with tense situations and pressure. It is deterimental when is becomes an excessive, irrational dread of everyday situations. The most common types of anxiety di...

Anorexia Nervosa
The main eating disorder, anorexia nervosa, involves extreme weight loss as a result of very strict dieting. The cause is a strong belief held by the patient that they are fat (despite their extreme thinness), and become terrified of putting on weight. O...