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DNA Replication’s Got a Good Beat, and Cancer Can Dance to It

05:50 EST 13 Nov 2017 | Genetic Engineering News

If cancer had ever been interviewed on American Bandstand about a new song, it might have echoed countless teenagers by saying, “It’s got a good beat and you can dance to it”—but only if a slow number had just been played. Cancer, it happens, has two left feet when it comes to DNA replication, which must proceed at a slow pace if cancer is to avoid tripping itself up. "We found that cancer cells copy their DNA rather slowly, because they have abnormal genomes and replicating DNA has to overcome many obstacles,” said Kumar Somyajit, Ph.D., a postdoc at the University of Copenhagen and the first author of a new study about the tempo of DNA replication. “When we remove their ability to copy their genomes slowly, the cancer cells die because they cannot cope with too many bumps on their DNA templates." The possibility that cancer ...

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