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Protective Thermostable Protein Exoshell Boosts Recombinant Protein Yield 100-Fold

05:27 EST 14 Nov 2017 | Genetic Engineering News

Scientists in Singapore have developed a bacterial protein nanoparticle that improves recombinant protein folding, increases functional expression yields up to 100-fold, and shields the internalized proteins from damage by heat, chemicals, and proteolysis. Scientists at the National University of Singapore (NUS), and the Nanyang Technological University, who developed the thermostable exoshell (tES), hope that the technology could help to address some of the problems with recombinant protein production, both for resaerch and industrial applications. “Our findings highlight the potential of using highly engineered nanometer-sized shells as a synthetic biology tool to dramatically affect the production and stability of recombinant proteins," claims lead researcher Chester Drum, M.D., Ph.D., assistant professor at the departments of medicine and biochemistry, at NUS Medicine, who is also a consultant cardiologist at the National University Hospital and director of the Clinical Trial Innovation Lab at the Translational Laboratory in Genetic Medicine (TLGM), A*STAR. The team reports ...

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