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Researchers reverse heart failure in Marfan mice

19:00 EST 13 Nov 2017 | AAAS

(Johns Hopkins Medicine) In experiments with mice that have a rodent form of Marfan syndrome, Johns Hopkins researchers report that even modestly increasing stress on the animals' hearts -- at levels well-tolerated in normal mice -- can initiate heart failure. The findings, described August 4 in the Journal of Clinical Investigation Insight, revealed a novel cellular pathway in heart tissue that leads to heart failure and may serve as a model for a new standard of treatment for children with this aggressive form of Marfan syndrome.

Original Article: Researchers reverse heart failure in Marfan mice

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