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Eager to avoid the complications that may arise if viral vectors are used to deliver components of the CRISPR/Cas9 gene-editing system, researchers have been busy developing nonviral nanoparticle carriers, such as lipid, polymeric, and gold nanoparticles. Now, at MIT, researchers have developed a new lipid nanoparticle that has an interesting twist: It packs chemically modified single guide RNA (sgRNA). By enhancing sgRNA, the researchers hope to protect it against nuclease degradation, and thereby boost efficiency of the overall CRISPR/Cas9 gene-editing system. According to the MIT team, which was led by Daniel G. Anderson, Ph.D., an associate professor of chemical engineering and a member of MIT’s Koch Institute, the new delivery technique cut out certain genes in about 80% of liver cells, the best success rate ever achieved with CRISPR in adult animals. Details about the new delivery system appeared November 13 in the journal Nature Biotechnology , ...
Original Article: CRISPR/Cas9 Delivery Goes Nano with Enhanced Guide RNANEXT ARTICLE
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...
Hepatology is the study of liver, gallbladder, biliary tree, and pancreas, and diseases associated with them. This includes viral hepatitis, alcohol damage, cirrhosis and cancer. As modern lifestyles change, with alcoholism and cancer becoming more promi...