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CRISPR/Cas9 Delivery Goes Nano with Enhanced Guide RNA

06:27 EST 14 Nov 2017 | Genetic Engineering News

Eager to avoid the complications that may arise if viral vectors are used to deliver components of the CRISPR/Cas9 gene-editing system, researchers have been busy developing nonviral nanoparticle carriers, such as lipid, polymeric, and gold nanoparticles. Now, at MIT, researchers have developed a new lipid nanoparticle that has an interesting twist: It packs chemically modified single guide RNA (sgRNA). By enhancing sgRNA, the researchers hope to protect it against nuclease degradation, and thereby boost efficiency of the overall CRISPR/Cas9 gene-editing system. According to the MIT team, which was led by Daniel G. Anderson, Ph.D., an associate professor of chemical engineering and a member of MIT’s Koch Institute, the new delivery technique cut out certain genes in about 80% of liver cells, the best success rate ever achieved with CRISPR in adult animals. Details about the new delivery system appeared November 13 in the journal Nature Biotechnology , ...

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