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Adoptive cell therapy (ACT) uses cancer reactive T-cells to effectively treat patients. However, several obstacles inhibit the successful use of ACT for cancer treatment. Current approaches for the expansion of T-cells may produce T-cells with a terminally differentiated phenotype that is associated with diminished anti-tumor activity and poor capacity for long-term persistence. Thus, there is a need for improved methods of obtaining an isolated population of effective T-cells for ACT.
Researchers at the NCI have developed a method of producing large populations of minimally-differentiated T-cells using an Akt inhibitor. The researchers discovered that inhibition of the serine/threonine kinase, Akt, also known as protein kinase B, effectively uncouples T-cell expansion from differentiation. This uncoupling allows for the generation of more robust T-cells with greater anti-tumor efficacy than differentiated T-cells. The researchers found that Akt inhibition also promotes the genetic and metabolic characteristics of long-lived memory T-cells. This discovery provides a method of producing an isolated population of cancer reactive T-cells suitable for ACT.
Crompton JG, et al.
van der Waart AB, et al.
The National Cancer Institute, Surgery Branch, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize a novel method of producing effective T-cell populations using Akt inhibitors.
Original Article: Methods of Producing Effective T-cell Populations Using Akt InhibitorsNEXT ARTICLE
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