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Membralin Protein Found Critical in Regulating Beta-Amyloid Production

03:41 EST 15 Nov 2017 | Genetic Engineering News

Researchers at the Sanford Burnham Prebys Medical Discovery Institute (SBP) say they have shown that membralin is critical for keeping Alzheimer's disease pathology in check. The study (“ ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity ”), published in  Nature Communications , demonstrates that membralin regulates the cell's machinery for producing beta-amyloid (or amyloid beta, Aβ), the protein that causes neurons to die in Alzheimer's disease. “Endoplasmic-reticulum-associated degradation (ERAD) is an important protein quality control system which maintains protein homeostasis. Constituents of the ERAD complex and its role in neurodegeneration are not yet fully understood. Here, using proteomic and FRET analyses, we demonstrate that the ER protein membralin is an ERAD component, which mediates degradation of ER luminal and membrane substrates. Interestingly, we identify nicastrin, a key component of the γ-secretase complex, as a membralin binding protein and membralin-associated ERAD substrate,” write the investigators. ...

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