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Pathogenic arboviruses including dengue, chikungunya, yellow fever and zika, are all spread by the mosquito Aedes Aegypti . Researchers at the University of California, Riverside (UCR), have now developed transgenic strains of this mosquito that stably express the Cas9 enzyme in their germline, making CRISPR genome editing fast and efficient, and opening up the potential to develop ‘gene drive’ strategies for controlling mosquito populations in the wild. As an initial proof of concept the researchers, headed by Omar Akbari, an assistant professor of entomology in UCR's College of Natural and Agricultural Sciences, disrupted different genes in the Cas9-expressing mosquito embryos, which affected vision, flight and blood feeding. “Overall, our results demonstrate that our simplified transgenic Cas9 system has improved capacity to rapidly induce highly efficient and specific targeted genome modifications, including gene disruptions, deletions, and insertions,” the researchers write in their published paper in the Proceedings of the ...
Original Article: Cas9 Expression in Mosquito Germlines Could Help Prevent Disease SpreadNEXT ARTICLE
Tropical Medicine is the study of diseases more commonly found in tropical regions than elsewhere. Examples of these diseases are malaria, yellow fever, Chagas disease, Dengue, Helminths, African trypanosomiasis, Leishmaniasis, Leprosy, Lymphatic filaria...
Genetic engineering is the process of manually adding new DNA to an organism. The goal is to add one or more new traits that are not already found in that organism. Examples of genetically engineered (transgenic) organisms currently on the market include...
Enzymes are proteins that catalyze (i.e., increase the rates of) chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical re...