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Pharmacodynamic Assay

20:00 EDT 31 Jul 2004 | NIH

This invention is a rapid, simple, sensitive flow cytometric assay for the pharmacodynamic analysis of histone deacetylase inhibitors in clinical development as novel anti-cancer agents. The assay can be performed on 50 microliters of whole blood, the equivalent of a finger stick. The assay can quantify simultaneously the effects of multiple classes of drug and thus be used for pharmacodynamic analysis of HDAC inhibitors in combination therapy.

IC: 
NCI
NIH Ref. No.: 
E-094-2004/0
Applications: 
  • Basic research and clinical research assay for evaluating anti-cancer therapeutics
  • Companion diagnostic
Provider Technology ID: 
968
Updated On: 
Nov 20, 2017
Date Published: 
Sunday, August 1, 2004
Provider Classifications: 
Publications: 
Patent Application: 
60/548,794
PCT/US2005/006236
11/467,080
15/208,324
15/445,975
Patent Authority: 
US
PCT
US
US
US
Patent Number: 
9,389,223
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NCI
NCI
Inventor Lab URL: 
http://ccr.cancer.gov/staff/staff.asp?profileid=7178
LPM FIrst Name: 
Kevin
LPM Last Name: 
Chang
LPM Address: 
9609 Medical Center Drive, Room 1E-530 (MSC 9702)
LPM City: 
Rockville
Inv Is lead: 
LPM Zip: 
20850-9702
LPM State: 
MD
LPM Phone: 
240-276-6910
LPM Suffix: 
Ph.D.
LPM Organization: 
NIH Office of Technology Transfer
LPM Fax: 
240-276-5504
DTDT Classification: 
Cancer
Diagnostics
Other
Cancer
Diagnostic
DTDT Description: 
Cancer
Cancer - Diagnostics
Cancer - Diagnostics - In Vitro: Other
Cancer
Diagnostic
Pat Filing Date: 
2004-02-27
2005-02-25
2006-08-24
2016-07-12
2017-02-28
Patent Issue Date: 
2016-07-12
Application Term: 
Disease Area Term: 
Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

Researchers at the NCI seek licensing and/or co-development research collaborations for this technology. Please contact John D. Hewes, Ph.D. at 240-276-5515 or john.hewes@nih.gov for more information.

E Number Only: 
E-094-2004
Inventor First Name: 
Jane
Eun Joo
Inventor Last Name: 
Trepel Neckers
Chung

Original Article: Pharmacodynamic Assay

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