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This invention is a rapid, simple, sensitive flow cytometric assay for the pharmacodynamic analysis of histone deacetylase inhibitors in clinical development as novel anti-cancer agents. The assay can be performed on 50 microliters of whole blood, the equivalent of a finger stick. The assay can quantify simultaneously the effects of multiple classes of drug and thus be used for pharmacodynamic analysis of HDAC inhibitors in combination therapy.
Researchers at the NCI seek licensing and/or co-development research collaborations for this technology. Please contact John D. Hewes, Ph.D. at 240-276-5515 or firstname.lastname@example.org for more information.
Original Article: Pharmacodynamic AssayNEXT ARTICLE
An assay is an analytic procedure for qualitatively assessing or quantitatively measuring the presence or amount or the functional activity of a target entity. This can be a drug or biochemical substance or a cell in an organism or organic sample. ...
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