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Duke University researchers have grown the first functional human skeletal muscle tissue entirely from induced human pluripotent stem cells (hPSCs). The achievement could feasibly allow scientists to generate skeletal muscle tissue for disease modelling and drug studies, and potentially for developing hPSC-based therapies for muscle-wasting diseases. "It's taken years of trial and error, making educated guesses and taking baby steps to finally produce functioning human muscle from pluripotent stem cells," comments Lingjun Rao, Ph.D., first author of the team’s published report in Nature Communications . “What made the difference are our unique cell culture conditions and 3D matrix, which allowed cells to grow and develop much faster and longer than the 2D culture approaches that are more typically used." The team’s paper, released today, is entitled “ Engineering Human Pluripotent Stem Cells into a Functional Skeletal Muscle Tissue .” Previous research has shown that skeletal muscle cells ...NEXT ARTICLE
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Track and monitor developments in stem cell research and commercial development. Follow the tabs above to read the latest global news, research, clinical trials on stem cells and follow companies active in the stem cell industry. BioPort...
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...