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Tissue Pixelation Chip Measures Spatial RNA Expression In Tumor Samples in Two Hours

04:03 EST 18 Jan 2018 | Genetic Engineering News

Scientists have developed a microchip-based RNA analysis technology that can directly measure gene expression spatially across samples of cancer tissue, within just a couple of hours. The chip’s developers, led by Rashid Bashir, Ph.D., and Farhad Kosari, Ph.D., at the Mayo-Illinois Alliance for Technology Based Healthcare, suggest that their “tissue pixelation” spatial amplification technology will provide greater insight into the expression profiles of patients’ tumors than current protein-based approaches, as well as representing a valuable research tool.  "Our method can detect messenger RNA expression, which can provide additional insight than just the final protein concentration," professor Bashir comments. In their published paper in Nature Communications (“ Pixelated spatial gene expression analysis from tissue ”) the scientists report using the technology to directly amplify and analyze the mRNA of the prostate cancer marker, topoisomerase II alpha (TOP2A), in frozen human prostate tissue xenografts grown in mice. “Our technique, which ...

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