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Study Suggests Novel Approach to Osteoarthritis Therapy

03:40 EST 15 Feb 2018 | Genetic Engineering News

Scientists at The Scripps Research Institute (TSRI) report why the risk of osteoarthritis increases as we age. They also describe a new approach for developing new therapies to maintain healthy joints. The study (“ FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis ”), which appears in Science Translational Medicine, suggests that FOXO proteins are responsible for the maintenance of healthy cells in the cartilage of our joints. “FoxO transcription factors protect against cellular and organismal aging, and FoxO expression in cartilage is reduced with aging and in OA [osteoarthritis]. To investigate the role of FoxO in cartilage, Col2Cre-FoxO1, 3, and 4 single knockout (KO) and triple KO mice (Col2Cre-TKO) were analyzed. Articular cartilage in Col2Cre-TKO and Col2Cre-FoxO1 KO mice was thicker than in control mice at 1 or 2 months of age. This was associated with increased proliferation of chondrocytes of Col2Cre-TKO ...

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