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Hepatitis B Infects Organ-on-a-Chip Platform

05:41 EST 15 Feb 2018 | Genetic Engineering News

For the first time, a real pathogen has instigated a real disease process in an artificial organ, and scientists are really, really pleased. As far as scientists are concerned, the whole point of an artificial organ—in this case, a liver-on-a-chip platform—is to simulate a real organ’s physiology, and that includes pathophysiology. By using an artificial liver to model the interactions between human tissue and an infectious agent—in this case, hepatitis B—scientists based at Imperial College London have opened a new front in disease research and, potentially, the development of new drugs. “This is the first time that organ-on-a-chip technology has been used to test viral infections,” said Marcus Dorner, Ph.D., a researcher at Imperial's School of Public Health. “Our work represents the next frontier in the use of this technology. We hope it will ultimately drive down the cost and time associated with clinical trials, which will benefit ...

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