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Scientists headed by team at the Karolinska Institutet in Sweden have identified a new approach to cancer therapy that involves blocking a single enzyme that plays a key role in how tumors respond to oxidative stress. Elias Arnér, Ph.D., and colleagues identified highly specific inhibitors of the selenium-containing TXN reductase 1 (TXNRD1) that were effective against multiple tumor types in mice, without showing any obvious toxicity to mitochondria or other cellular systems. Based on their early preclinical in vivo studies, the researchers project that targeted TXNRD1 inhibitors could represent a promising new approach to cancer therapy. “My hope is that we will be able to develop new treatments, effective against multiple forms of cancer but with few side effects," comments Dr. Arnér, who is based at the Karolinska Institutet’s department of medical biochemistry and biophysics. “This seems to work in mouse models, and we are therefore hopeful that ...
Original Article: Blocking Single Enzyme in Mice Kills Tumors Without ToxicityNEXT ARTICLE
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Enzymes are proteins that catalyze (i.e., increase the rates of) chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical re...
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