Blocking Single Enzyme in Mice Kills Tumors Without Toxicity

05:41 EST 15 Feb 2018 | Genetic Engineering News

Scientists headed by team at the Karolinska Institutet in Sweden have identified a new approach to cancer therapy that involves blocking a single enzyme that plays a key role in how tumors respond to oxidative stress. Elias Arnér, Ph.D., and colleagues identified highly specific inhibitors of the selenium-containing TXN reductase 1 (TXNRD1) that were effective against multiple tumor types in mice, without showing any obvious toxicity to mitochondria or other cellular systems. Based on their early preclinical  in vivo studies, the researchers project that targeted TXNRD1 inhibitors could represent a promising new approach to cancer therapy. “My hope is that we will be able to develop new treatments, effective against multiple forms of cancer but with few side effects," comments Dr. Arnér, who is based at the Karolinska Institutet’s department of medical biochemistry and biophysics. “This seems to work in mouse models, and we are therefore hopeful that ...

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