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Sorting out "non-canonical" autophagy

11:49 EST 15 Feb 2018 | Nature Publishing

Canonically, LC3 lipidation has been associated with autophagy pathways but it becomes increasingly clear that this modification can also occur during autophagy-unrelated processes. In this issue, Florey and colleagues find that the WD40 domain of ATG16L1 is dispensable for LC3 lipidation during starvation-induced autophagy but required for its lipidation during several other membrane-based processes that are different from autophagy. This finding opens the door for the analysis of the functions of LC3 lipidation in these pathways.

Original Article: Sorting out "non-canonical" autophagy

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