PhaseBio Wins $2.8M SBIR Grant to Advance Lead Candidate

05:56 EST 27 Feb 2018 | Genetic Engineering News

PhaseBio Pharmaceuticals said today it won a $2.8 million Fast Track Small Business Innovation Research (SBIR) grant from the NIH toward clinical development of its lead candidate PB1046 for pulmonary arterial hypertension (PAH). PB1046 is a first-in-class, sustained-release vasoactive intestinal peptide (VIP) analog already under study in an ongoing Phase I clinical trial ( NCT03315507 ). The trial, PB1046-PT-CL-000, is an open-label, dose-titration study designed to assess the safety, tolerability, and hemodynamic effects of individually dose-titrated PB1046 injected weekly over 8 weeks in adults with PAH who have a permanently implanted hemodynamic monitor (CardioMEMS™ HF System) in the distal pulmonary artery. The Phase I portion of the grant will fund the ongoing exploratory trial, while the Phase II portion will support a larger, Phase II trial in PAH set to launch by mid 2018, PhaseBio said. PB1046 is a once-weekly VIP receptor agonist designed to ...

Original Article: PhaseBio Wins $2.8M SBIR Grant to Advance Lead Candidate


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