Track topics on Twitter Track topics that are important to you
Immune cells in the brain have a trigger, and when it is pulled, it prompts immune cells to degrade toxic β-amyloid (Aβ) proteins. This new finding, from Sanford Burnham Prebys Medical Research Institute (SBP), helps explain why a faulty trigger appears to raise the risk of Alzheimer’s disease. Increasing the genetic expression of the trigger—a way of pulling the trigger more often—could prevent or reduce the severity of Alzheimer’s disease and other neurodegenerative disorders. The trigger is called triggering receptor expressed on myeloid cells 2 (TREM2). TREM2’s amyloid-binding mechanism and its potential use against Alzheimer’s were discussed in two papers that appeared March 7 in the journal Neuron . "Our first paper identifies how Aβ binds to TREM2, which activates neural immune cells called microglia to degrade Aβ, possibly slowing Alzheimer's disease pathogenesis," said Huaxi Xu, Ph.D., professor and director of SBP's Neuroscience Initiative. "The second study ...
Original Article: Alzheimer’s Amyloid Gets Immune System TrimNEXT ARTICLE
Of all the types of Dementia, Alzheimer's disease is the most common, affecting around 465,000 people in the UK. Neurons in the brain die, becuase 'plaques' and 'tangles' (mis-folded proteins) form in the brain. People with Al...
Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...