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Scientists at the Salk Research Institute say they have discovered how the molecule ERRγ gives brown fat its energy-expending identity and potentially offering a new therapeutic target for diseases related to obesity. The study (“ ERRγ Preserves Brown Fat Innate Thermogenic Activity ”) is published in Cell Reports . “Brown adipose tissue (BAT) adaptively transfers energy from glucose and fat into heat by inducing a gene network that uncouples mitochondrial electron transport. However, the innate transcription factors that enable the rapid adaptive response of BAT are unclear. Here, we identify estrogen-related receptor gamma (ERRγ) as a critical factor for maintaining BAT identity. ERRγ is selectively expressed in BAT versus WAT [white adipose tissue], in which, in the absence of PGC1α, it drives a signature transcriptional network of thermogenic and oxidative genes in the basal (i.e., thermoneutral) state,” write the investigators. “Mice lacking ERRγ in adipose tissue (ERRγKO mice) ...NEXT ARTICLE
Obesity is the condition in which excess fat has accumulated in the body (mostly in subcutaneous tissues). clinical obesity is considered to be present when a person has a BMI of over 30 (Oxford Dictionary of Medicine). It is becoming increasing common i...
Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...