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Scientists at the Salk Research Institute say they have discovered how the molecule ERRγ, or estrogen-related receptor gamma, gives brown fat its energy-expending identity and potentially offers a new therapeutic target for diseases related to obesity. The study (“ ERRγ Preserves Brown Fat Innate Thermogenic Activity ”) is published in Cell Reports . “Brown adipose tissue (BAT) adaptively transfers energy from glucose and fat into heat by inducing a gene network that uncouples mitochondrial electron transport. However, the innate transcription factors that enable the rapid adaptive response of BAT are unclear. Here, we identify estrogen-related receptor gamma (ERRγ) as a critical factor for maintaining BAT identity. ERRγ is selectively expressed in BAT versus WAT [white adipose tissue], in which, in the absence of PGC1α [p eroxisome proliferator-activated receptor gamma coactivator 1-alpha] , it drives a signature transcriptional network of thermogenic and oxidative genes in the basal (i.e., thermoneutral) state,” ...
Original Article: Treating Obesity with Brown Fat–Related MoleculeNEXT ARTICLE
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Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...