Treating Obesity with Brown Fat–Related Molecule

06:08 EDT 14 Mar 2018 | Genetic Engineering News

Scientists at the Salk Research Institute say they have discovered how the molecule ERRγ, or estrogen-related receptor gamma, gives brown fat its energy-expending identity and potentially offers a new therapeutic target for diseases related to obesity. The study (“ ERRγ Preserves Brown Fat Innate Thermogenic Activity ”) is published in  Cell Reports . “Brown adipose tissue (BAT) adaptively transfers energy from glucose and fat into heat by inducing a gene network that uncouples mitochondrial electron transport. However, the innate transcription factors that enable the rapid adaptive response of BAT are unclear. Here, we identify estrogen-related receptor gamma (ERRγ) as a critical factor for maintaining BAT identity. ERRγ is selectively expressed in BAT versus WAT [white adipose tissue], in which, in the absence of PGC1α [p eroxisome proliferator-activated receptor gamma coactivator 1-alpha] , it drives a signature transcriptional network of thermogenic and oxidative genes in the basal (i.e., thermoneutral) state,” ...

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