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Cell Sex a Factor in Nanoparticle Uptake and Efforts to Change Cell Fate

07:07 EDT 14 Mar 2018 | Genetic Engineering News

A nanoparticle may have little surface area, but it does represent a wide-open frontier in nanomedicine, which seeks to deploy nanoparticles in imaging, drug delivery, and cell reprogramming applications. In recent years, the discipline has been exploring the nanoparticle’s nanobio interface, that is, the composition of the nanoparticle’s protein corona. The nanobio interface, scientists believe, may influence the outcome of a range of nanomedicine interventions. Scientists are particularly interested in understanding discrepancies that arise between nanoparticle performance in the laboratory and that in the clinic. In their studies of the nanobio interface, scientists have evaluated potentially relevant factors, such as cell type, cell shape, and incubating temperature. Most recently, these studies have considered yet another factor—cell sex. Investigators from Brigham and Women's Hospital (BWH) and colleagues at Stanford University, McGill University, and University of California, Berkeley, have investigated whether differences between male versus female cells may ...

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