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Preclinical Characterization of Therapeutic Antibodies Targeted at the Carboxy-terminus of Sonic Hedgehog

11:35 EDT 14 Mar 2018 | Drug Discovery Development

Even though the Shh pathway is mainly quiescent in adults, the safety of Shh-targeting with therapeutic antibodies was questioned initially because not only does the N-terminus of the Shh protein play an important role in embryonic development, but Shh also plays a poorly understood role in tissue homeostasis and repair in adults.
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Oncotarget

Original Article: Preclinical Characterization of Therapeutic Antibodies Targeted at the Carboxy-terminus of Sonic Hedgehog

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