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[Comment] Tivantinib for advanced hepatocellular carcinoma: is MET still a viable target?

03:57 EDT 4 Apr 2018 | The Lancet

The HGF-MET receptor pathway represents an attractive therapeutic target for hepatocellular carcinoma because of its crucial role in hepatocellular carcinoma development. Tivantinib, a putative MET inhibitor, did not improve overall survival compared with placebo in the METIV-HCC study, as reported in the Lancet Oncology by Lorenza Rimassa and colleagues,1 potentially casting doubt on the role of MET inhibition as a viable therapeutic strategy for patients with hepatocellular carcinoma. METIV-HCC was a randomised, double-blind, placebo-controlled, phase 3 trial of oral tivantinib (120 mg twice daily) compared with placebo in patients with advanced hepatocellular tumours with high MET-expression (staining intensity score of ≥2 in ≥50% of tumour cells) who had disease progression after previous sorafenib therapy.

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