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Genentech, Kineta to Partner on Non-Opioid Pain Treatments

07:14 EDT 16 Apr 2018 | Genetic Engineering News

Genentech, a member of the Roche Group, has agreed to exclusively license and develop Kineta's α9/α10 nicotinic acetylcholine receptor (nAChR) antagonists as targets for a non-opioid treatment for chronic pain, through a collaboration that Kineta said today could generate for it up to $359 million-plus. The α9/α10 nAChR antagonists could emerge as novel targets for treating chronic neuropathic pain, Kineta said, citing preclinical data showing that investigational compounds that specifically target the receptor reduced pain behaviors in animal models and demonstrated disease-modifying effects, including reduced inflammation and nerve protection at the site of injury. “The α9α10 nAChR represents a mechanistically distinctive target for modifying the disease course of chronic pain. Presently available pain medications act on a limited number of pharmacological targets that treat, but do not prevent, disease progression,” University of Utah researchers Baldomera M. Olivera, Ph.D., and J. Michael McIntosh, M.D., and colleagues, concluded in ...

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