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Antimicrobials Evolved by Computer Show Fitness against Antibiotic-Resistant Bacteria

07:14 EDT 16 Apr 2018 | Genetic Engineering News

Scientists at MIT and the Catholic University of Brasilia say they have come up with a streamlined approach to developing antimicrobial peptides as potential drugs to fight antibiotic-resistant bacteria. Their novel strategy, which relies on a computer algorithm that mimics the natural process of evolution, has already yielded one potential drug candidate that successfully killed bacteria in mice. "We can use computers to do a lot of the work for us, as a discovery tool of new antimicrobial peptide sequences," says C é sar de la Fuente-N úñ ez, Ph.D., an MIT postdoc and Areces Foundation Fellow. "This computational approach is much more cost-effective and much more time-effective." Dr. de la Fuente-N úñ ez and Octavio Franco, Ph.D., of the Catholic University of Brasilia and the Dom Bosco Catholic University, are the corresponding authors of the paper (“ In Slico Optimization of a Guava Antimicrobial Peptide Enables ...

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