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Genetically altered broadly neutralizing antibodies protect monkeys from HIV-like virus

20:00 EDT 15 Apr 2018 | AAAS

(NIH/National Institute of Allergy and Infectious Diseases) Two genetically modified broadly neutralizing antibodies (bNAbs) protected rhesus macaques from an HIV-like virus, report scientists at the National Institute of Allergy and Infectious Diseases (NIAID). After introducing genetic mutations into two potent HIV bNAbs, researchers prepared intravenous infusions of two bNAbs. Single infusions of each modified bNAb protected monkeys against weekly exposures to simian-human immunodeficiency virus (SHIV) up to 37 weeks, compared with a median of three weeks in 12 monkeys receiving no antibody.

Original Article: Genetically altered broadly neutralizing antibodies protect monkeys from HIV-like virus

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