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[Comment] Soil-transmitted helminth treatment: multiple-drug regimens

20:14 EDT 16 Apr 2018 | The Lancet

In the past decade, deworming programmes targeting soil-transmitted helminths (STHs) have been scaled up, with 640 million individuals treated in 2016.1 This progress has in part been a result of the generous donations of albendazole by GlaxoSmithKline and mebendazole by Johnson & Johnson. However, these benzimidazole drugs have two main limitations: (1) low efficacy against Trichuris trichiura and variable efficacy against hookworm,2 and (2) the risk of emergence of drug-resistant parasites as a result of their increased use.

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