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Scientists at the Karolinska Institute in Sweden say they have developed a new disease model for neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS’ that can be used to develop new immunotherapies. The model is described in a paper (“ Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling ”) in Nature Immunology . “The cytokine transforming growth factor-β (TGF-β) regulates the development and homeostasis of several tissue-resident macrophage populations, including microglia. TGF-β is not critical for microglia survival but is required for the maintenance of the microglia-specific homeostatic gene signature. Under defined host conditions, circulating monocytes can compete for the microglial niche and give rise to long-lived monocyte-derived macrophages residing in the central nervous system (CNS). Whether monocytes require TGF-β for colonization of the microglial niche and maintenance of CNS integrity is unknown,” write the investigators. “We found that abrogation of TGF-βsignaling in CX3CR1+ monocyte-derived macrophages led ...
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Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...
Allergies Automimmune Disease Human Papillomavirus (HPV) Immunology Vaccine Immunology is the study of immunity and the defence mechanisms of the body. A greater understanding of immunology is needed to develop vaccines, understand ...