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Efficient control of leukaemia with treatment by dual immune-checkpoint blockade

20:00 EDT 16 Apr 2018 | AAAS

(Luxembourg Institute of Health) Chronic lymphocytic leukaemia (CLL) is a haematological malignancy. When infiltrating tissues, CLL cells come in contact with healthy cells, including immune cells. Researchers from the Luxembourg Institute of Health (LIH) succeeded in characterising in depth the composition of immune cells and circulating cytokines of the CLL microenvironment in mouse models using mass cytometry. Based on this knowledge, they propose an immunotherapeutic strategy with two immune checkpoint inhibitors that efficiently blocks disease development in preclinical tests.

Original Article: Efficient control of leukaemia with treatment by dual immune-checkpoint blockade

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