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Silica-Coated Nanodiamonds for Imaging and Delivery of Therapeutic Agents

10:12 EDT 26 Apr 2018 | NIH

The NCI Radiation Oncology Branch and the  NHLBI Laboratory of Single Molecule Biophysics seek parties to co-develop fluorescent  nanodiamonds for use as in vivo and in vitro optical tracking probes toward commercialization.  

NCI and NHLBI investigators invented a robust and easily implemented method of synthesizing silica-coated nanodiamonds for imaging and therapeutic applications. A patent estate covering these methods is offered for licensing to commercial entities. The method generally includes coating nanodiamonds with a silica precursor, e.g, tetraethylorthosilicate (TEOS), inside liposomes. The liposomes are then removed to yield a final product that is stable, monodisperse, and easy to functionalize. 

IC: 
NCI
NIH Ref. No.: 
E-175-2012
Advantages: 
  • Small size
  • Physiologically inert carrier
  • Monodisperse
  • Stable in aqueous solution
  • Readily functionalized
  • Biological activity is determined more efficiently than chemical analysis
  • High Specificity and selectivity
Applications: 
  • Imaging
  • Drug delivery
Development Status: 

Prototype

Updated On: 
Apr 17, 2018
Provider Classifications: 
Publications: 
Patent Application: 
61/672,996
61/711,702
Patent Authority: 
US Provisional
US Provisional
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NCI
NHLBI
Inventor Lab URL: 
https://ccr.cancer.gov/Radiation-Oncology-Branch/martin-w-brechbiel
https://irp.nih.gov/pi/keir-neuman
LPM FIrst Name: 
John
LPM Last Name: 
Hewes
Inv Is lead: 
LPM Phone: 
240-276-5515
LPM Organization: 
NCI - National Cancer Institute
DTDT Classification: 
Diagnostics
Research Materials
Therapeutics
DTDT Description: 
Diagnostics
Research Materials
Therapeutics
Pat Filing Date: 
2012-07-18
2012-10-09
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/16351080
https://doi.org/10.1063/PT.3.1204
https://www.ncbi.nlm.nih.gov/pubmed/21389265
https://www.ncbi.nlm.nih.gov/pubmed/18033700
Publication Caption: 
PMID 16351080
DOI 10.1063/PT.3.1204
PMID 21389265
PMID 18033700
Publication Title: 

Yu SJ, et al. Bright fluorescent nanodiamonds: no photobleaching and low cytotoxicity. 

Wilson RM. Nanodiamonds are promising quantum probes of living cells.

Chow EK, et al. Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment. 

Krueger A. New carbon materials: biological applications of functionalized nanodiamond materials.

Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

Licensing only

E Number Only: 
E-175-2012
Inventor First Name: 
Martin
Keir
Inventor Last Name: 
Brechbiel
Neuman

Original Article: Silica-Coated Nanodiamonds for Imaging and Delivery of Therapeutic Agents

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