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Virally Mediated Gene Therapy For The Control Of Chronic Or Persistent Pain

20:00 EDT 31 May 1999 | NIH

Current treatments for pain, especially chronic pain, are only partially effective and can eventually involve procedures that are invasive or associated with unacceptable side effects. In vivo gene transfer could be used to directly modulate pain and provide a long-term pain control. This invention describes a method of using an adenovirus or an adeno-associated virus that are genetically engineered to deliver DNA encoded peptides or proteins to neurons involved in the transmission of pain. The invention provides for a novel means to treat chronic pain by administering a beta-endorphin-expressing recombinant adenovirus into the subarachnoid space. The recombinant virus infects the pia mater connective tissue cells and the infected cells express the fusion protein, wherein the fusion protein is cleaved and the neuroactive product is secreted into spinal cord parenchymal tissue in an amount effective to treat the chronic pain but not significantly affecting basal nociceptive responses. The invention demonstrates a gene transfer approach to treatment of chronic pain disorders or cancer pain, and may be generalized to spinal cord injury or neurodegenerative disorders.

IC: 
NIDCR
NIH Ref. No.: 
E-044-1998-0
TAB No: 
TAB-372
Provider Technology ID: 
372
Updated On: 
May 6, 2018
Provider Classifications: 
Date Published: 
Tuesday, June 1, 1999
Patent Application: 
60/100,901
PCT/US99/22103
09/787,660
Publications: 
Patent Authority: 
US
PCT
US
Patent Number: 
6,596,269
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NIDCR
NIDCR
NIDCR
NIDCR
LPM FIrst Name: 
Yun
LPM Last Name: 
Mei
LPM Address: 
6701 Democracy Blvd, 1 Democracy Plaza, Rm 687
LPM City: 
Bethesda
Inv Is lead: 
LPM Zip: 
20817-4878
LPM State: 
MD
LPM Phone: 
301-827-4639
LPM Suffix: 
M.D.
LPM Organization: 
NIH Office of Technology Transfer
LPM Fax: 
301-496-1005
DTDT Classification: 
Central Nervous System
Therapeutics
Narcotics and Analgesics
DTDT Description: 
Central Nervous System
Central Nervous System - Therapeutics
Central Nervous System - Therapeutics - Neurological Therapeutics: Narcotics and Analgesics
Pat Filing Date: 
1998-09-23
1999-09-23
2001-08-24
Patent Issue Date: 
2003-07-22
Disease Area Term: 
Collaboration Sought: 
Yes
Institute or Center: 
E Number Only: 
E-044-1998-0
Inventor First Name: 
Michael
Robert
Alan
Andrew
Inventor Last Name: 
Iadarola
Caudle
Finegold
Mannes

Original Article: Virally Mediated Gene Therapy For The Control Of Chronic Or Persistent Pain

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