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AAV4 Vector And Uses Thereof

19:00 EST 30 Nov 1998 | NIH

These patent applications describe the cloning and characterization of the full-length genome of adeno-associated virus type 4 (AAV4). AAV4, like other members of the AAV family, may be useful as a vector for gene therapy.

When compared to AAV2, AAV4 may be better suited as a vector due to its larger size -- which permits efficient encapsidation of a larger recombinant genome -- and its greater buoyant density -- which allows for easier separation of AAV4 from contaminating helper virus. Other characteristics of AAV4 which distinguish it from AAV2 and AAV3 are its expanded promoter region, its distinct capsid protein, its different tissue tropism and its ability to bind hemagluttinin (HA). While AAV4 has several distinguishing characteristics from AAV2 and AAV3 it also shares significant homology, greater than 90%, with the Rep proteins of AAV2 and AAV3.

Studies using a lacZ reporter gene suggest that AAV4 can transduce human, monkey, and rat cells. Other studies comparing transduction efficiencies in a number of cell lines, competition cotransduction experiments and the effect of trypsin on transduction efficiency suggest that the cellular receptor for AAV4 is distinct from that of AAV2.

IC: 
NHLBI
NIH Ref. No.: 
E-066-1996-0
TAB No: 
TAB-367
Provider Technology ID: 
367
Updated On: 
May 9, 2018
Provider Classifications: 
Date Published: 
Tuesday, December 1, 1998
Patent Application: 
60/025,934
PCT/US97/16266
09/254,747
10/719,311
12/719,671
13/933,382
14/459,550
Publications: 
Patent Authority: 
US
PCT
US
US
US
US
US
Patent Number: 
7,718,424
8,507,267
8,846,389
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NHLBI
NHLBI
NHLBI
Inventor Lab URL: 
http://irp.nih.gov/pi/john-chiorini
LPM FIrst Name: 
Yun
LPM Last Name: 
Mei
LPM Address: 
6701 Democracy Blvd, 1 Democracy Plaza, Rm 687
LPM City: 
Bethesda
LPM Zip: 
20817-4878
Inv Is lead: 
LPM State: 
MD
LPM Phone: 
301-827-4639
LPM Suffix: 
M.D.
LPM Organization: 
NIH Office of Technology Transfer
LPM Fax: 
301-496-1005
DTDT Classification: 
Gene Based Therapies
Therapeutics
Other
DTDT Description: 
Gene Based Therapies
Gene Based Therapies - Therapeutics
Gene Based Therapies - Therapeutics: Other
Pat Filing Date: 
1996-09-11
1997-09-11
1999-11-26
2003-11-20
2010-03-08
2013-07-02
2014-08-14
Patent Issue Date: 
2010-05-18
2013-08-13
2014-09-30
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/9261407
Publication Caption: 
PMID 9261407
Publication Title: 

Chiorini JA, et al.

Disease Area Term: 
Collaboration Sought: 
Yes
Institute or Center: 
Related Patents: 
6,468,524
Related Patent Publish Date: 
953704800
Related Patent Application: 

09/532,594

Related Patent Authority: 
US
Related Invention: 
E-071-2000-0
E Number Only: 
E-066-1996-0
Inventor First Name: 
John
Robert
Brian
Inventor Last Name: 
Chiorini
Kotin
Safer

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