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Pigment epithelium-derived factor (PEDF), a unique 50 kD protein secreted by retinal pigment epithelium (RPE) cells, has trophic activity. This invention describes the biological activity of PEDF, a method of enhancing neuron cell survival and a method of inhibiting glial cell proliferation, as well as purified antibodies to PEDF and an immunoassay. This technology can be used to develop therapeutics for the treatment of inflammatory, vascular, degenerative, and dystrophic diseases of the retina and central nervous system (CNS).
Taniwaki T, et al.
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...