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Pigment Epithelium Derived Factor: Characterization of Its Novel Biological Activity and Sequences Encoding and Expressing the Protein

20:00 EDT 30 Jun 1996 | NIH

Pigment epithelium-derived factor (PEDF), a unique 50 kD protein secreted by retinal pigment epithelium (RPE) cells, has trophic activity. This invention describes the biological activity of PEDF, a method of enhancing neuron cell survival and a method of inhibiting glial cell proliferation, as well as purified antibodies to PEDF and an immunoassay. This technology can be used to develop therapeutics for the treatment of inflammatory, vascular, degenerative, and dystrophic diseases of the retina and central nervous system (CNS).

IC: 
NEI
NIH Ref. No.: 
E-185-1992-1
TAB No: 
TAB-236
Advantages: 
  • Enhance neuronal cell survival
  • Inhibit glial cell proliferation
Applications: 
  • Alzheimer's disease
  • Huntington's disease
  • Glutamate poisoning
  • Parkinson's disease
Provider Technology ID: 
236
Updated On: 
May 14, 2018
Provider Classifications: 
Date Published: 
Monday, July 1, 1996
Patent Application: 
08/257,963
PCT/US95/07201
Publications: 
Patent Authority: 
US
PCT
Patent Number: 
5,840,686
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NEI
NINDS
NINDS
LPM FIrst Name: 
Lynne
LPM Last Name: 
Huang
LPM Address: 
Technology Transfer Center, NCI 9609 Medical Center Dr. Room 1E-542 Rockville MD 20852 (Hand Delivery Or Courier Service Use)
LPM City: 
Rockville
LPM Zip: 
20850-9702
Inv Is lead: 
LPM State: 
MD
LPM Phone: 
240-276-5530
LPM Suffix: 
Ph.D.
LPM Organization: 
NIH Office of Technology Transfer
LPM Fax: 
240-276-5504
DTDT Classification: 
Ophthalmology
Diagnostics
Therapeutics
Biological
Other
DTDT Description: 
Ophthalmology
Ophthalmology - Diagnostics
Ophthalmology - Therapeutics
Ophthalmology - Therapeutics: Biological
Ophthalmology - Other
Pat Filing Date: 
1994-06-07
1995-06-06
Patent Issue Date: 
1998-11-24
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/7760030
Publication Caption: 
PMID 7760030
Publication Title: 

Taniwaki T, et al.

Application Term: 
Disease Area Term: 
Collaboration Sought: 
Yes
Institute or Center: 
Related Patents: 
6,319,687
7,511,009
6,451,763
7,179,621
Related Patent Publish Date: 
788767200
1028869200
809672400
791013600
775112400
965106000
1123650000
Related Patent Application: 

08/367,841

10/216,373

08/520,373

08/377,710

08/279,979

09/630,629

11/201,443

Related Patent Authority: 
US
US
US
US
US
US
US
Related Invention: 
E-185-1992-2
E-185-1992-3
E Number Only: 
E-185-1992-1
Inventor First Name: 
Gerald
Takayuki
Yukihiro
Inventor Last Name: 
Chader
Taniwaki
Sugita

Original Article: Pigment Epithelium Derived Factor: Characterization of Its Novel Biological Activity and Sequences Encoding and Expressing the Protein

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