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Gut Microbe Byproducts May Cool Brain Inflammation

07:15 EDT 17 May 2018 | Genetic Engineering News

Neurological disorders such as multiple sclerosis may be worsened by proinflammatory astrocyte neurotoxins, which may be more plentiful if astrocytes are exposed to certain microglia secretions, which may be promoted—or limited—by metabolites produced by gut microbes. This chain of events, which was uncovered by scientists based at Brigham and Women’s Hospital (BMH), contains links that could be weakened or reinforced. Perhaps the most intriguing link is near the start of the chain. This link, which consists of gut microbes capable of releasing inflammation-limiting metabolites, could lead to new therapies for multiple sclerosis and other neurological disorders. The BWH team recently reported that it has identified “positive and negative regulators that mediate the microglial control of astrocytes.” Details appeared May 16 in the journal Nature , in an article entitled “ Microglial Control of Astrocytes in Response to Microbial Metabolites .” The new research focuses on the influence ...

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