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Transmission-Blocking Malaria Vaccine

19:00 EST 10 Jan 2013 | NIH

There is no vaccine for malaria, and there is growing resistance to existing anti-malarial drugs. Sexual stage-specific antigens are of interest as vaccine candidates because disruption of these antigens would reduce the fertility and, thus, the infectivity of the parasite.

This invention claims methods and compositions for delivering a Plasmodium P47 vaccine or antibody to P47 to prevent
Plasmodium falciparum or Plasmodium vivax malaria. P47 and other antigens have been mentioned as potential transmission-blocking vaccines due to their surface location on gametes. The gene for P47 antigens is also well characterized. Recent discoveries have noted that P47 allows the parasite to suppress or evade the immune system, thereby ensuring the mosquitoes' survival. Recent discoveries have also shown the mechanism by which P47 enables survival of the parasite by manipulation of the mosquito immune system. Based on the critical role of P47 antigens in transmission, the disruption of the function of P47 by various means can be an innovative and forceful means to control and/or reduce the prevalence of malaria.

IC: 
NIAID
NIH Ref. No.: 
E-222-2012-0
TAB No: 
TAB-2506
Advantages: 
  • Single protein malaria transmission-blocking vaccine.
  • Cost-effective, simple manufacturing process for vaccine.
  • Potentially lower-cost malarial vaccine for developing/developed countries.
Applications: 
  • Malaria vaccine, diagnostic and therapeutic.
Development Status: 
  • Pre-clinical
  • In vitro data available
  • In vivo data available (animal)
Provider Technology ID: 
2506
Updated On: 
May 16, 2018
Provider Classifications: 
Date Published: 
Friday, January 11, 2013
Patent Application: 
61/684,333
PCT/US2013/055372
14/421,964
Publications: 
2016-03-24 00:00:00
2016-03-24 00:00:00
2016-03-24 00:00:00
2016-03-24 00:00:00
Patent Authority: 
US
PCT
US
Licensing Contacts: 
LPM Address: 
  --
United States
LPM Address: 
  --
United States
Lead Inventor: 
Inventor IC: 
NIAID
NIAID
Inventor Lab URL: 
https://irp.nih.gov/pi/carolina-barillas-mury
LPM FIrst Name: 
Peter
LPM Last Name: 
Tung
LPM Address: 
BG 5601FL RM 6D38 MSC 9804 5601 FISHERS LN
LPM City: 
Rockville
LPM Zip: 
20852-9804
Inv Is lead: 
LPM State: 
MD
LPM Phone: 
240-669-5483
LPM Suffix: 
Ph.D., M.B.A.
LPM Organization: 
NIH Office of Technology Transfer
DTDT Classification: 
Infectious Diseases
Diagnostics
Parasitic
Other
Therapeutics
Anti-parasitic
Other
Vaccines
Parasite
Research Materials
RM Catalog - reviewed and deemed appropriate for RM Catalog
Other
DTDT Description: 
Infectious Diseases
Infectious Diseases - Diagnostics
Infectious Diseases - Diagnostics: Parasitic
Infectious Diseases - Diagnostics: Other
Infectious Diseases - Therapeutics
Infectious Diseases - Therapeutics: Anti-parasitic
Infectious Diseases - Therapeutics: Other
Infectious Diseases - Vaccines
Infectious Diseases - Vaccines: Parasite
Infectious Diseases - Research Materials
Infectious Diseases - Research Materials (appropriate for RM Catalog)
Infectious Diseases - Other
Pat Filing Date: 
2012-08-17
2013-08-16
2015-02-16
Publication Link: 
https://www.ncbi.nlm.nih.gov/pubmed/22623529
Publication Caption: 
PMID 22623529
Publication Title: 

Molina-Cruz A, et al.

Disease Area Term: 
Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

The National Institute of Allergy and Infectious Diseases (NIAID) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize malaria vaccines, diagnostics and therapeutics. For collaboration opportunities, please contact Tristan J. Mahyera at tristan.mahyera@nih.gov or 301-827-0251.

E Number Only: 
E-222-2012-0
Inventor First Name: 
Carolina
Alvaro
Inventor Last Name: 
Barillas-Mury
Molina-Cruz

Original Article: Transmission-Blocking Malaria Vaccine

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