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Full-Length cDNA Clone Representing the Consensus Sequence of the RNA Genome of a Human Norovirus (strain MD145-12) That Encodes Biologically Active Proteins

20:00 EDT 31 May 2008 | NIH

The invention provides for a full-length cloned cDNA copy of the RNA genome of a predominant norovirus strain (Genogroup II.4) designated MD145-12 that was associated with human gastrointestinal illness. The noroviruses, which were formerly known as "Norwalk-like" viruses are estimated to cause 23 million cases of acute gastroenteritis in the USA each year. The virus has been designated into category B of the CDC biodefense-related priority pathogens because it can be used as an agent of bioterrorism. The subject cDNA clone of the virus encodes proteins of the MD145-12 strain that, when expressed in vitro, exhibit properties that would be expected from those produced by the original infectious virus. This cDNA clone is presently the only source to obtain norovirus proteins to facilitate studies aimed at developing control strategies such as vaccines and therapeutic drugs.

IC: 
NIAID
NIH Ref. No.: 
E-212-2003-0
Provider Technology ID: 
903
Updated On: 
May 16, 2018
Date Published: 
Sunday, June 1, 2008
Provider Classifications: 
Publications: 
Patent Authority: 
EIR
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NIAID
NIAID
NIAID
Inventor Lab URL: 
https://irp.nih.gov/pi/kim-green
LPM FIrst Name: 
Admin. Licensing
LPM Last Name: 
Specialist (ALS)
LPM Address: 
This People Record Is Used To Identify Technology Families That Are Fully Inactive. The Basic Definition Is: 1. All Patents Expired Or Lapsed For Non-payment Of Annuities/maintenance Fees 2. All Patent Applications Abandoned 3. No Licenses Currently Act
Inv Is lead: 
LPM Organization: 
NIH Office of Technology Transfer
DTDT Classification: 
Infectious Diseases
Vaccines
Non-AIDS (only)
Research Materials
DTDT Description: 
Infectious Diseases
Infectious Diseases - Vaccines
Infectious Diseases - Vaccines - Viral: Non-AIDS
Infectious Diseases - Research Materials
Additional Patents: 
Research Material -- Patent protection is not being pursued for this technology
Disease Area Term: 
Collaboration Sought: 
Yes
Institute or Center: 
Collaboration Opportunity: 

The Laboratory of Infectious Diseases, NIAID, NIH, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize reagents derived from a cDNA clone of the genome of a predominant human norovirus strain, Genogroup II.4. Please contact Kim Y. Green at kgreen@niaid.nih.gov for more information.

Related Patent Authority: 
EIR
EIR
EIR
Related Invention: 
E-198-2003-0
E-214-2003-0
E-283-2003-0
E Number Only: 
E-212-2003-0
Inventor First Name: 
Lisbeth Kim
Stanislav
Gael
Inventor Last Name: 
Green
Sosnovtsev
Belliot

Original Article: Full-Length cDNA Clone Representing the Consensus Sequence of the RNA Genome of a Human Norovirus (strain MD145-12) That Encodes Biologically Active Proteins

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