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A Prophylactic and Therapeutic for Preventing and Treating Tularemia by Rapid Activation of Host Cells and Antigen Recognition

20:00 EDT 30 Jun 2008 | NIH

The invention is a composition and method for prophylactic and therapeutic treatment of tularemia caused by Francisella tularensis comprised of Cationic Liposome DNA Complexes (CLDC) complexed with noncoding DNA and membrane antigens isolated from F. tularensis strain LVS (MPF). F. tularensis is category A pathogen (as designated by the NIH) that was previously weaponized by both the former Soviet Union and the United States of America and is currently a potential bioweapon and bioterrorism threat. Furthermore, tularemia is endemic to the U.S. (majority of the cases occurring in the Midwest) and Europe. The prophylactic and therapeutic activities of this invention rely in part on rapid activation of host cells and recognition of bacterial antigens. In vivo studies in mice show that CLDC + MPF elicit protective immunity against pneumonic tularemia when administered shortly (days) prior to exposure to aerosols of virulent F. tularensis. The method can be applicable for eliciting immune response in other infectious diseases.

IC: 
NIAID
NIH Ref. No.: 
E-095-2008-0
TAB No: 
TAB-1767
Advantages: 
  • Rapid induction of protective immunity against F. tularensis
  • Avoids antibiotic resistance associated with current therapies
Applications: 
  • Prophylactic and therapeutic for Tularemia
  • Biodefense agent
  • Method is applicable to other infectious diseases, particularly for pathogens that are enveloped or encapsulated (i.e. Pseudomonas aeruginosa, Neisseria meningiditis, Yersinia pestis and Influenza)
Development Status: 

In vitro and in vivo data are available

Provider Technology ID: 
1767
Updated On: 
May 16, 2018
Provider Classifications: 
Date Published: 
Tuesday, July 1, 2008
Patent Application: 
61/030,984
PCT/US2009/001176
12/919,204
Publications: 
Patent Authority: 
US
PCT
US
Licensing Contacts: 
Lead Inventor: 
Inventor IC: 
NIAID
Inventor Lab URL: 
https://irp.nih.gov/pi/catharine-bosio
LPM FIrst Name: 
Jeffrey
LPM Last Name: 
Thruston
LPM Address: 
BG 5601FL RM 2G56 MSC 9804 5601 FISHERS LN
LPM City: 
Bethesda
Inv Is lead: 
LPM Zip: 
20892-9804
LPM State: 
MD
LPM Phone: 
301-594-5179
LPM Organization: 
NIH Office of Technology Transfer
DTDT Classification: 
Infectious Diseases
Therapeutics
Anti-bacterial
Vaccines
Bacterial
Brochure - In-vivo Data
Brochure - In-vitro Data
DTDT Description: 
Infectious Diseases
Infectious Diseases - Therapeutics
Infectious Diseases - Therapeutics: Anti-bacterial
Infectious Diseases - Vaccines
Infectious Diseases - Vaccines: Bacterial
In-vivo Data
In-vitro Data
Pat Filing Date: 
2008-02-24
2009-02-24
2010-08-24
Publication Title: 

PowerPoint slide presentation of invention can be provided upon request.

Disease Area Term: 
Collaboration Sought: 
Yes
Institute or Center: 
E Number Only: 
E-095-2008-0
Inventor First Name: 
Catharine
Inventor Last Name: 
Bosio

Original Article: A Prophylactic and Therapeutic for Preventing and Treating Tularemia by Rapid Activation of Host Cells and Antigen Recognition

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